منابع مشابه
Radiation Induced Bystander Effect
Introduction: Radiation effects observed in cells that are not irradiated are known as non-targeted effects. Radiation induced bystander effect (RIBE) as a kind of non-targeted effect has been introduced in recent years. RIBE occurs in unexposed cells which are related to adjacent or distant irradiated cells. RIBE contradict with "target theory" which necessitates radiation tr...
متن کاملRadiation Bystander Effects Mechanism
Introduction: Radiation Induced Bystander Effect (RIBE) which cause radiation effects in non-irradiated cells, has challenged the principle according to which radiation traversal through the nucleus of a cell is necessary for producing biological responses. What is the mechanism of this phenomenon? To have a better understanding of this rather ambiguous concept substantial number of original ...
متن کاملSignaling in Radiation-Induced Bystander Effects
Although radiation-induced bystander effects have been well described over the past decade, the mechanisms of the signaling processes involved in the bystander phenomenon remain unclear. In the present study, using the Columbia University charged particle microbeam, we found that mitochondrial DNA–depleted human skin fibroblasts (R) showed a higher bystander mutagenic response in confluent mono...
متن کاملBystander effects in radiation-induced genomic instability.
Exposure of GM10115 hamster-human hybrid cells to X-rays can result in the induction of chromosomal instability in the progeny of surviving cells. This instability manifests as the dynamic production of novel sub-populations of cells with unique cytogenetic rearrangements involving the "marker" human chromosome. We have used the comet assay to investigate whether there was an elevated level of ...
متن کاملRadiation-induced adaptive responses and bystander effects.
A classical paradigm [correction of paradym] of radiation biology asserts that all radiation effects on cells, tissues and organisms are due to the direct action of radiation. However, there has been a recent growth of interest in the indirect actions of radiation including the radiation-induced adaptive response, the bystander effect, low-dose hypersensitivity, and genomic instability, which a...
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ژورنال
عنوان ژورنال: Acta Oncologica
سال: 2006
ISSN: 0284-186X,1651-226X
DOI: 10.1080/02841860600768960